association between il12a rs568408, il12b rs3212227 and il-12 receptor rs383483 polymorphisms and risk of pulmonary tuberculosis
نویسندگان
چکیده
background interleukine-12 (il-12) induced interferon-γ (ifn- γ) production and development of t cells into th1 cells, which has a critical role in immunity to intracellular pathogens. objectives the current study aimed to evaluate the possible association between il12a rs568408, il12b rs3212227 as well as il-12 receptor (il-12r) rs383483 polymorphisms and pulmonary tuberculosis (ptb). methods this case-control study was conducted on 174 confirmed ptb patients and 177 healthy subjects in a sample of southeast iranian population. genotyping was performed by the tetra amplification refractory mutation system- polymerase chain reaction (t-arms-pcr) method. results the frequencies of gg, ga and aa genotypes of il12a rs568408 variant in cases and controls were 58.9%, 38.5%, 1.7% and 61.6%, 37.3%, 1.1%, respectively. regarding rs3212227 variant, the frequencies of aa, ac and cc genotypes in cases and controls were 47.1%, 54.4%, 7.5% and 50.8%, 43.5%, 5.7%, respectively. concerning il12r rs383483 polymorphism, the frequencies of aa, ag and gg in cases and controls were 39.1%, 31.4%, 29.5% and 40.2%, 25.3%, 34.5%, respectively. there was no significant difference in allele and genotype frequency of il12a rs568408, il12b rs3212227 and il-12r rs383483 polymorphisms between patients with ptb and control groups (p > 0.05). conclusions the findings of the current study show that neither il12a rs568408 and il12b rs3212227 nor il-12r rs383483 polymorphisms are associated with the risk of ptb in our population. further studies with larger sample sizes and various ethnicities are needed to certify our findings.
منابع مشابه
Interactions of IL-12A and IL-12B polymorphisms on the risk of cervical cancer in Chinese women.
PURPOSE Accumulative evidence suggests that interleukin-12 (IL-12) plays a central role in the Th1 responses and thus participates in the carcinogenesis of human papillomavirus-related cervical cancer. We hypothesized that potentially functional polymorphisms in IL12A and IL12B may individually and jointly contribute to cervical cancer risk. EXPERIMENTAL DESIGN We genotyped IL12A rs568408 [3'...
متن کاملAntibodies to hepatitis B virus surface antigen and interleukin 12 and interleukin 18 gene polymorphisms in hemodialysis patients
BACKGROUND The interleukin (IL)18 rs360719 CC genotype is associated with the development of antibodies to hepatitis B virus surface antigen (anti-HBs) in hemodialysis (HD) patients. IL18 shares biological properties with IL12 in promoting the T-hepler 1 (Th1) system. We studied whether polymorphisms in the IL12A 3` untranslated region (UTR) and IL12B 3`UTR may contribute to anti-HBs developmen...
متن کاملassociation between tlr8 and tlr9 gene polymorphisms and pulmonary tuberculosis
conclusions tlr8 rs3764880 and tlr9 rs148805533 polymorphisms may not be risk factors for susceptibility to tuberculosis in a sample of iranian population. larger studies are required to validate our findings. results the allelic and genotypic frequencies of the tlr8 rs3764880 did not differ significantly between ptb and the controls. no significant difference was found between the groups regar...
متن کاملLack of Association Between miRNA-146a rs2910164 and miRNA-499 rs3746444 Gene Polymorphisms and Susceptibility to Pulmonary Tuberculosis
Single-nucleotide polymorphisms (SNPs) in miRNAsmay alter its expression levels or processing and contribute to susceptibility to a wide range of diseases. Our study aimed to evaluate the possible association between miRNA-146a rs2910164 and miRNA-499 rs3746444 polymorphisms and susceptibility to pulmonary tuberculosis (PTB) in a sample of Iranian population. This case- control study was perfor...
متن کاملAssociation between IRGM polymorphisms and tuberculosis risk
BACKGROUND The human immunity-related GTPase M (IRGM) is involved in regulating autophagy against invading pathogens. Recently, inconsistent results have been reported about the association between IRGM polymorphisms and tuberculosis risk in several studies. METHODS We searched the PubMed, Embase, and Web of Knowledge, and extracted data from eligible articles to estimate the associations bet...
متن کاملRole of interleukin-12 gene polymorphisms in the onset risk of cancer: a meta-analysis
Many molecular epidemiologic studies have explored the possible links between interleukin-12 (IL-12) polymorphisms and various cancers. However, results from these studies remain inconsistent. This meta-analysis is aimed to shed light on the associations between three common loci (rs568408, rs2243115, rs3212227) of IL-12 gene and overall cancer risk. Our meta-analysis finally included 33 studie...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
archives of clinical infectious diseasesجلد ۱۲، شماره ۱، صفحات ۰-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023